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Hydrochloric Acid → 1-(4-Fluoro-2-nitrophenyl)piperidine-4-carboxylic acid

HRID 722235
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인쇄 미리보기

반응식

HRID 722235 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[NH:12]1[CH2:17][CH2:16][CH:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]1.CN1C(=O)CCC1.Cl>O>[F:8][C:5]1[CH:6]=[CH:7][C:2]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2)=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 37734-Piperidinecarboxylic acidHCID 13387N-methyl-2-pyrrolidoneHCID 677672,5-Difluoronitrobenzene

생성물 1

HCID 218838811-(4-Fluoro-2-nitrophenyl)piperidine-4-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

The mixture consisting of 1.62 g of 2,5-difluoronitrobenzene, 1.9 g of piperidine-4-carboxylic acid and 10 ml of NMP was heated with stirring to 80° C. for 2 hours. After it had been allowed to cool, 30 ml of water were added and the mixture was made weakly acidic using 2N hydrochloric acid and stirred at RT. The precipitated solid was filtered off with suction and dried under reduced pressure.

후처리

  1. temperaturewas heated
  2. temperatureto cool
  3. stirringstirred at RT
  4. filtrationThe precipitated solid was filtered off with suction
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-c1bef3095cf04279991447ded646426f
출처 데이터셋
uspto-grants-2006_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07138414B2

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