Water → 4-Piperidinecarboxylic acid, 1-(2-amino-4-fluorophenyl)-, hydrochloride (1:1)

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[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]2)=[C:4]([N+:17]([O-])=O)[CH:3]=1.[Sn](Cl)[Cl:21].O>C(OCC)(=O)C>[ClH:21].[NH2:17][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[N:8]1[CH2:9][CH2:10][CH:11]([C:14]([OH:16])=[O:15])[CH2:12][CH2:13]1

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실험 절차

The solution of 804 mg of 1-(4-fluoro-2-nitrophenyl)piperidine-4-carboxylic acid in 40 ml of ethyl acetate was admixed with 3.8 g of tin(II) chloride and stirred at RT for 2 hours. 50 ml of water were then added and the mixture was filtered through a clarifying layer. The ethyl acetate phase was removed, dried over sodium sulfate and concentrated by rotary evaporator, leaving a semisolid residue which was subjected directly to further reaction.