Water → HCID 69439418, 화합물

HRID 722238노트

반응식

HRID 722238 반응식
[Cl:1][C:2]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:3]=1[C:4]([NH:6][C:7](=[O:25])[NH:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([OH:24])=[O:23])[CH2:18][CH2:17]1)=[O:5].[OH-].[Na+:33].O>C(O)(C)C>[Na+:33].[Cl:1][C:2]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:3]=1[C:4]([NH:6][C:7](=[O:25])[NH:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:17][CH2:18][CH:19]([C:22]([O-:24])=[O:23])[CH2:20][CH2:21]1)=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 12148754AVE2865

생성물 1

HCID 69439418HCID 69439418, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

The solution of 100 mg of 1-{2-[3-(2-chloro-4,5-difluorobenzoyl)ureido]-4-fluoro-phenyl}piperidine-4-carboxylic acid in 8 ml of isopropanol at 60° C. is admixed with the equimolar amount of 2N sodium hydroxide solution and, after the addition of 20 ml of water, cooled slowly with stirring. The precipitated product is filtered off with suction, washed with isopropanol and water and dried under reduced pressure.

후처리

  1. customat 60° C.
  2. temperaturecooled slowly
  3. filtrationThe precipitated product is filtered off with suction
  4. washwashed with isopropanol and water
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-3b5c905885d243f981e23f7008678800
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138414B2

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