Sodium borohydride → Carbamic acid 3-[4-(2-hydroxy-ethoxy)-phenyl]-isoxazol-5-ylmethyl ester

HRID 72318노트

반응식

HRID 72318 반응식
[BH4-].[Na+].C([O:5][C:6](=O)[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:19]=[C:18]([CH2:20][O:21][C:22](=[O:24])[NH2:23])[O:17][N:16]=2)=[CH:11][CH:10]=1)C>C1COCC1>[OH:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:19]=[C:18]([CH2:20][O:21][C:22](=[O:24])[NH2:23])[O:17][N:16]=2)=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 66617666HCID 66617666, 화합물

생성물 1

HCID 46892997Carbamic acid 3-[4-(2-hydroxy-ethoxy)-phenyl]-isoxazol-5-ylmethyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5 equivalents of NaBH4 was added to 200 mg of the compound [4-(5-carbamoyloxymethyl-isoxazol-3-yl)-phenoxy]-acetic acid ethyl ester in Example 47 while stirring in the presence of a 10 ml THF/5 ml water solvent. After stirring for 12 hours, the solvent was distilled off under reduced pressure and 20 ml of 1-N HCl solution was added to the reactants, followed by extraction three times with 20 ml of ethyl acetate. The obtained organic layer was put under reduced pressure to obtain carbamic acid 3-[4-(2-hydroxy-ethoxy)-phenyl]-isoxazol-5-ylmethyl ester as a desired compound.

후처리

  1. distillationthe solvent was distilled off under reduced pressure and 20 ml of 1-N HCl solution
  2. additionwas added to the reactants
  3. extractionfollowed by extraction three times with 20 ml of ethyl acetate

출처 및 근거

ORD 기록
ord-2260209b56684bc0859a3ead21aba189
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828992B2

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