Hydrochloric Acid → 4-Chloro-2-methyl-3-(trifluoromethyl)aniline

HRID 723707노트

반응식

HRID 723707 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]C(=O)C(C)(C)C)=[C:4]([CH3:15])[C:3]=1[C:16]([F:19])([F:18])[F:17].Cl>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([CH3:15])[C:3]=1[C:16]([F:17])([F:18])[F:19]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21874848N-[4-chloro-2-methyl-3-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

생성물 1

HCID 179957894-Chloro-2-methyl-3-(trifluoromethyl)aniline수율 76%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N-(4-Chloro-2-methyl-3-trifluoromethylphenyl)-2,2-dimethyl-propionamide 1.0 g, 3.4 mmol) was added to a 1:1 mixture (15 mL) of concentrated HCl and ethanol and heated at reflux for overnight. The reaction was cooled and concentrated in vacuo to give a tan solid which was then partitioned between EtOAc and saturated NaHCO3. The organic layer was separated, washed with water, brine, dried (Na2SO4), filtered and concentrated to give compound 760C (0.54g, 76%) as a brown oily solid.

후처리

  1. temperatureheated
  2. temperatureat reflux for overnight
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated in vacuo
  5. customto give a tan solid which
  6. customwas then partitioned between EtOAc and saturated NaHCO3
  7. customThe organic layer was separated
  8. washwashed with water, brine
  9. dry with materialdried (Na2SO4)
  10. filtrationfiltered
  11. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e79b05be6b1746ca8edb2186708f812d
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141578B2

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