Triethylamine → 2-Cyano-3-fluoropyridine

HRID 723717노트

반응식

HRID 723717 반응식
[F:1][C:2]1[CH:3]=[N+:4]([O-])[CH:5]=[CH:6][CH:7]=1.C[Si]([C:13]#[N:14])(C)C.C(N(CC)CC)C>C(#N)C>[C:13]([C:3]1[C:2]([F:1])=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:14]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 82115Trimethylsilyl cyanideHCID 123084Pyridine, 3-fluoro-, 1-oxide

생성물 1

HCID 70604082-Cyano-3-fluoropyridine수율 70%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

3-Fluoropyridine-1-oxide (10.0g, 88.4 mmol), trimethylsilylcyanide (26.32g, 265.3 mmol), and triethylamine (17.89g, 177 mmol) were reacted in 90 mL of acetonitrile utilizing the procedure described in example 762B. Purification of the crude by silica gel chomatography using CH2Cl2 as eluent gives compound 771B (7.5g, 70%) as a light yellow solid.

후처리

  1. customPurification of the crude by silica gel chomatography

출처 및 근거

ORD 기록
ord-08b764105c2d4d27b5ea0492d2a71faa
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141578B2

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