Methyl iodide → 3-Methoxythioanisole

HRID 724259노트

반응식

HRID 724259 반응식
CI.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([SH:11])[CH:8]=[CH:9][CH:10]=1.[C:12](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][CH3:12])[CH:6]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 849893-Methoxybenzenethiol

생성물 1

HCID 2811823-Methoxythioanisole수율 99.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Methyl iodide (14.67 ml, 0.235 mol) was added dropwise to a solution of 3-methoxy-benzenethiol (30 g, 0.214 mol) and potassium carbonate (29.6 g, 0.214 mol) in acetone (400 ml) under nitrogen at 3° C. The reaction was allowed to warm to room temperature and the solvent was removed under reduced pressure. The residue was diluted with water (300 ml) and the aqueous layer was extracted with diethylether (3×200 ml). The combined organic extracts were dried over MgSO4 and the solvent was removed under reduced pressure to give 1-Methoxy-3-methylsulfanyl-benzene (32.87 g) as a pale yellow liquid.

후처리

  1. customthe solvent was removed under reduced pressure
  2. additionThe residue was diluted with water (300 ml)
  3. extractionthe aqueous layer was extracted with diethylether (3×200 ml)
  4. dry with materialThe combined organic extracts were dried over MgSO4
  5. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-964d102472ee430686ec0e088d7065cf
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141586B2

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