Hydrochloric Acid → 4-Amino-1-methylcyclohexanol hydrochloride

HRID 724266노트

반응식

HRID 724266 반응식
[ClH:1].[OH:2][C:3]1([CH3:17])[CH2:8][CH2:7][CH:6]([NH:9]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1>O1CCOCC1>[ClH:1].[NH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH3:17])([OH:2])[CH2:4][CH2:5]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21877240cis-4-(Boc-amino)-1-methylcyclohexanol

생성물 1

HCID 218771344-Amino-1-methylcyclohexanol hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

4M Hydrochloric acid in dioxan (40 ml, 160 mmol) was added to a solution of the more polar diastereoisomer of tert-butyl 4-hydroxy-4-methylcyclohexylcarbamate (405 g, 1.77 mmol) in dioxan (5 ml). The mixture was stirred for 3 h then the solvent was removed under reduced pressure and the residue dried in vacuo to afford a single diastereoisomer of 4-amino-1-methylcyclohexanol hydrochloride (305 mg) as a white solid.

후처리

  1. customthe solvent was removed under reduced pressure
  2. customthe residue dried in vacuo

출처 및 근거

ORD 기록
ord-18e0849939324c97954f0f4961f1614b
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141586B2

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