Methyl 5-chloro-2-(2-phenylpyrrolidin-1-yl)nicotinate → 5-Chloro-2-(2-phenylpyrrolidin-1-yl)nicotinic acid

HRID 72457

반응식

HRID 72457 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:16][CH2:15][CH2:14][CH:13]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8]>CO.[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:16][CH2:15][CH2:14][CH:13]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 1

HCID 67958237Methyl 5-chloro-2-(2-phenylpyrrolidin-1-yl)nicotinate

생성물 1

HCID 679586975-Chloro-2-(2-phenylpyrrolidin-1-yl)nicotinic acid수율 108%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

To an ice cooled solution of methyl 5-chloro-2-(2-phenylpyrrolidin-1-yl)nicotinate (D72) (165 mg, 0.520 mmol) in methanol (10 ml), 10N NaOH (10 ml) was added. The mixture was heated under reflux overnight. After cooled to room temperature, the mixture was concentrated in vacuo. The residue was diluted with water (10 ml), acidified with 2.5N HCl (pH 1-2), and the resulting mixture was extracted with ethyl acetate (2×10 ml). The organic solution was washed with brine (20 ml), dried over Na2SO4 and evaporated in vacuo to afford the title compound (D98) (170 mg) as a red solid.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux overnight
  3. concentrationthe mixture was concentrated in vacuo
  4. additionThe residue was diluted with water (10 ml)
  5. extractionthe resulting mixture was extracted with ethyl acetate (2×10 ml)
  6. washThe organic solution was washed with brine (20 ml)
  7. dry with materialdried over Na2SO4
  8. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-81d088ce54304cf29e2e7ba529ec83ca
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828987B2

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