Peracetic Acid → HCID 14607966, 화합물

HRID 724751노트

반응식

HRID 724751 반응식
[CH3:1][O:2][C:3](=[O:10])[CH2:4][C:5]1[CH2:9][CH2:8][CH2:7][CH:6]=1.C([O-])(=[O:13])C.[Na+].C(OO)(=O)C>C(Cl)(Cl)Cl.C(O)(=O)C>[CH3:1][O:2][C:3](=[O:10])[CH2:4][CH:5]1[CH2:9][CH:8]2[O:13][CH:7]2[CH2:6]1

참가 물질

6

반응물 3

HCID 6585Peracetic AcidHCID 517045Sodium AcetateHCID 12282108Methyl (cyclopent-1-en-1-yl)acetate

생성물 1

HCID 14607966HCID 14607966, 화합물수율 424.1%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6212Chloroform용매

반응 조건

온도
35 °C

실험 절차

43.46 g (0.31 mol) of cyclopentenylacetic acid methyl ester are dissolved in 80 ml of chloroform. After the addition of 4 g of sodium acetate, 82.51 g of a 40% solution of peracetic acid in acetic acid are added dropwise thereto, with stirring, the temperature being maintained at about 35° C. The reaction mixture is then stirred for a further 5 hours at 35° C. The reaction mixture is extracted with 5% sodium hydrogen carbonate solution and then twice with water. The organic phase is then separated off and dried and residual peroxide is destroyed with sodium sulfite. After distillation of the organic phase there are obtained 32.3 g of 3,4-epoxycyclopentylacetic acid methyl ester (66.5% of theory).

후처리

  1. additionare added dropwise
  2. stirringThe reaction mixture is then stirred for a further 5 hours at 35° C
  3. extractionThe reaction mixture is extracted with 5% sodium hydrogen carbonate solution
  4. customThe organic phase is then separated off
  5. customdried
  6. customresidual peroxide is destroyed with sodium sulfite
  7. distillationAfter distillation of the organic phase there

출처 및 근거

ORD 기록
ord-b52ae5b3f873495394226c06ff7b3f79
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05705316

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