Acetic Anhydride → 3',5'-Dichloro-4'-hydroxyacetanilide

HRID 724752노트

반응식

HRID 724752 반응식
Cl.[NH2:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([OH:10])=[C:5]([Cl:11])[CH:4]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>O>[Cl:9][C:7]1[CH:8]=[C:3]([CH:4]=[C:5]([Cl:11])[C:6]=1[OH:10])[NH:2][C:12](=[O:14])[CH3:13]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 162059Phenol, 4-amino-2,6-dichloro-, hydrochloride (1:1)

생성물 1

HCID 100821803',5'-Dichloro-4'-hydroxyacetanilide수율 95%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

Into a 500 ml round bottom flask (fitted with a magnetic stirrer), water (200 ml) was mixed with 4-amino-2,6-dichlorophenol hydrochloride (20 g) until the solid was completely dissolved. The resulting solution was warmed to 70° C., and to it was added acetic anhydride (11 g) and the resulting solution was stirred for 1 hour. Upon cooling, crystals of 3',5'-dichloro-4'-hydroxyacetanilide were formed (19.6 g, 95% yield).

후처리

  1. dissolutionwas completely dissolved
  2. temperatureUpon cooling

출처 및 근거

ORD 기록
ord-b07a513a7d604496b867697bd9c8770f
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05705357

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