Dimethylformamide → N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine

HRID 724825

반응식

HRID 724825 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][N:18]=[C:17](Cl)[CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.C(O)CCO.[CH3:27][N:28](C)[CH:29]=O>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]([N:28]([CH3:29])[CH3:27])[CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 104421,3-PropanediolHCID 9905031N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine

생성물 1

HCID 21948226N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine

실험 절차

300 mg (0.95 mmol) of N-(3-chloro-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine (see Example 1), 5.3 ml of 1,3-propanediol and 3.0 ml of dimethylformamide are stirred for 43 hours at 105°. After concentration and repeated chromatography (methylene chloride:methanol=98:2) N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine is obtained; m.p. 176°-178°, FAB-MS: 326 (M+ +H).

후처리

  1. concentrationAfter concentration

출처 및 근거

ORD 기록
ord-c3482e11c2e84dc49fa14c44b98d45d5
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05705502

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