Triethylamine → (r)-Aspartic acid ethyl ester
반응식
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[CH2:10](N(CC)CC)[CH3:11]>C(O)C.Cl>[CH3:10][CH2:11][O:8][C:7](=[O:9])[C@@H:2]([CH2:3][C:4]([OH:6])=[O:5])[NH2:1]참가 물질
5
실험 절차
13.31 g of D-aspartic acid (0.1 mole) are dissolved in 135 ml of absolute ethanol containing 8.7 g of dry hydrogen chloride. The reaction mixture is stirred for about 2 hr. The solution is diluted by addition of 250 ml of absolute ethanol. Triethylamine is then added dropwise until the solution becomes alkaline. After standing for 16 hr at +4° C., the obtained crystals are filtered, washed successively with cold absolute ethanol and ether, then dried. The reaction yields 11.5 g of D-aspartic acid β-ethyl ester (71%).
후처리
- waitAfter standing for 16 hr at +4° C.
- filtrationthe obtained crystals are filtered
- washwashed successively with cold absolute ethanol and ether
- customdried
출처 및 근거
- ORD 기록
- ord-6624f76bdaf74ef0a4b527870acddc6a
- 출처 데이터셋
- uspto-grants-1998_01
- 특허 번호
- US05705522
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