4-Bromo-1,1-difluorobut-1-ene → 4,4-Difluorobut-3-enyl thioacetate

HRID 724999

반응식

HRID 724999 반응식
[C:1]([O-:4])(=[S:3])[CH3:2].[K+].Br[CH2:7][CH2:8][CH:9]=[C:10]([F:12])[F:11]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]([O:4][CH2:7][CH2:8][CH:9]=[C:10]([F:12])[F:11])(=[S:3])[CH3:2]

참가 물질

4

반응물 2

HCID 27822404-Bromo-1,1-difluorobut-1-eneHCID 23670855Potassium ethanethioate

생성물 1

HCID 538607444,4-Difluorobut-3-enyl thioacetate수율 38.9%

시약·촉매·용매 1

HCID 74236Tetrabutylammonium Bromide촉매

실험 절차

Potassium thioacetate (1.98 g), 4-bromo-1,1-difluorobut-1-ene (3.0 g) and tetra-n-butylammonium bromide (0.3 g, catalyst) were stirred at the ambient temperature under nitrogen for 5 hours and stored for 18 hours. The mixture was distilled using a Kugelrohr apparatus to give 4,4-difluorobut-3-enyl thioacetate as a colourless liquid (1.12 g); 1H NMR δ 2.25(2H,m); 2.30(3H,s); 2.90(2H,t); 4.20(1H,m); (bp 115° C. at 120 mmHg).

후처리

  1. distillationThe mixture was distilled

출처 및 근거

ORD 기록
ord-1befadaa56fc4f8abe6fd1b59c888580
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05705516

연결된 노트

불러오는 중…