반응식
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[N:5][C:6]([N:12]2[CH2:15][CH:14]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=3)[CH2:13]2)=[C:7]([CH:11]=1)[C:8](O)=[O:9].Cl.[NH2:30][C:31]1([C:34]2[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=2)[CH2:33][CH2:32]1>>[F:28][C:2]([F:1])([F:27])[C:3]1[CH:4]=[N:5][C:6]([N:12]2[CH2:15][CH:14]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:25])[F:26])[N:18]=3)[CH2:13]2)=[C:7]([CH:11]=1)[C:8]([NH:30][C:31]1([C:34]2[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=2)[CH2:33][CH2:32]1)=[O:9]참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound (D181) (75 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid (D130) (77 mg, 0.189 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (43.04 mg, 0.189 mmol).
출처 및 근거
- ORD 기록
- ord-b1cc043b5ca74ef0b57e42026d14aeb7
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08828987B2
연결된 노트
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