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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 72523생성일: 2026년 10월 26일

Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/72523

반응식

참여 물질

역할이름HCID투입량
반응물Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
반응물5-(Trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acidHCID 86697877—
생성물Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoateHCID 8669788168.4%

반응 단계

The title compound (D181) (75 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid (D130) (77 mg, 0.189 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (43.04 mg, 0.189 mmol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08828987B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-b1cc043b5ca74ef0b57e42026d14aeb7
출처 메모uspto-grants-2014_09