반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[O:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][N:9]([C:13](OC(C)(C)C)=O)[CH2:8]1.ClC1[N:45]=[CH:44][C:43]([Cl:46])=[CH:42][C:25]=1[C:26]([NH:28][C:29]1([C:32]2[CH:41]=[CH:40][C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:34][CH:33]=2)[CH2:31][CH2:30]1)=[O:27]>>[Cl:46][C:43]1[CH:44]=[N:45][C:13]([N:9]2[CH2:10][CH2:11][CH2:12][CH:7]([CH2:6][O:5][C:4]3[CH:20]=[CH:21][CH:22]=[C:2]([F:1])[CH:3]=3)[CH2:8]2)=[C:25]([CH:42]=1)[C:26]([NH:28][C:29]1([C:32]2[CH:33]=[CH:34][C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:40][CH:41]=2)[CH2:31][CH2:30]1)=[O:27]참가 물질
3
실험 절차
The title compound (D203) (97 mg) was prepared according to the experimental procedure described in Description 160 starting from tert-butyl 3-((3-fluorophenoxy)methyl)piperidine-1-carboxylate (D45) (100 mg, 0.323 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D97) (59 mg, 0.161 mmol).
출처 및 근거
- ORD 기록
- ord-fd19a8d074d14285b2fe826d89f7c259
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08828987B2
연결된 노트
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