Hydrochloric Acid → 5-(2-Anilino-4-thiazolyl)-2,3-dihydroxybenzonitrile hydrochloride

HRID 725425

반응식

HRID 725425 반응식
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([OH:14])[C:8]([OH:13])=[C:9]([CH:12]=1)[C:10]#[N:11])=O.[C:15]1([NH:21][C:22]([NH2:24])=[S:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[ClH:25]>CN(C)C=O>[ClH:25].[NH:21]([C:22]1[S:23][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([OH:14])[C:8]([OH:13])=[C:9]([CH:12]=2)[C:10]#[N:11])[N:24]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 676454PhenylthioureaHCID 214590655-(Bromoacetyl)-2,3-dihydroxybenzonitrile

생성물 1

HCID 214591825-(2-Anilino-4-thiazolyl)-2,3-dihydroxybenzonitrile hydrochloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3.8 g of 5-(bromoacetyl)-2,3-dihydroxybenzonitrile dissolved in 25 ml of N,N-dimethylformamide are treated with N-phenylthiourea and stirred at 100° for 5 hours. Thereafter, the solvent is removed by evaporation. The residue is treated with 200 ml of 1N sodium carbonate solution and extracted three times with 100 ml of methylene chloride each time. The combined organic phases are washed with water, dried over sodium sulfate and evaporated. The residue is chromatographed on 30 g of silica gel with ethyl acetate. The thus-obtained crude product is treated with 40 ml of 1N hydrochloric acid, evaporated and crystallized from acetone. There is obtained 5-(2-anilino-4-thiazolyl)-2,3-dihydroxybenzo- nitrile hydrochloride of m.p. 245°-247°.

후처리

  1. customThereafter, the solvent is removed by evaporation
  2. additionThe residue is treated with 200 ml of 1N sodium carbonate solution
  3. extractionextracted three times with 100 ml of methylene chloride each time
  4. washThe combined organic phases are washed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated
  7. customThe residue is chromatographed on 30 g of silica gel with ethyl acetate
  8. customThe thus-obtained crude product
  9. customevaporated
  10. customcrystallized from acetone

출처 및 근거

ORD 기록
ord-1d63e7bb57064665b5a5e86effa6985b
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05705703

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