Sodium Hydroxide → HCID 57378659, 화합물
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[F:1][C:2]1[CH:3]=[N:4][C:5]([O:8][CH:9]2[CH2:12][N:11]([C:13]3[N:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][C:14]=3[C:15]([NH:17][C:18]3([C:21]4[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[CH:23][CH:22]=4)[CH2:20][CH2:19]3)=[O:16])[CH2:10]2)=[N:6][CH:7]=1.[OH-].[Na+]>C1OCCOC1.O>[F:1][C:2]1[CH:3]=[N:4][C:5]([O:8][CH:9]2[CH2:12][N:11]([C:13]3[N:34]=[CH:33][C:32]([C:35]([F:38])([F:36])[F:37])=[CH:31][C:14]=3[C:15]([NH:17][C:18]3([C:21]4[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:29][CH:30]=4)[CH2:19][CH2:20]3)=[O:16])[CH2:10]2)=[N:6][CH:7]=1참가 물질
4
실험 절차
To a solution of methyl 4-(1-(2-(3-((5-fluoropyrimidin-2-yl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate (D182) (35 mg, 0.065 mmol) in a mixture 1-4 dioxane/water (3 ml/1 ml) 1M NaOH (0.098 ml, 0.098 mmol) was added. The mixture stirred 24 h at room temperature. After solvent evaporation, 1N HCl solution was added up to pH2. The solid precipitate was filtered off and washed with diethylether to afford the title compound (E48) (27 mg)