N-Methylbutylamine → Acetamide, 2-bromo-N-butyl-N-methyl-

To a solution cooled to -20° C. of 11.9 ml of bromoacetyl bromide in 180 ml of ether there were added 26 g of butylmethyl amine in solution in 120 ml of ether and then the temperature returned to 20° C. The mixture was stirred for 30 minutes diluted with water and extracted with ether. The ether phase was evaporated to dryness under reduced pressure and the 27.4 g of residue were distilled under reduced pressure (0.05 mbar) at 79/83° C. to obtain. 19.36 g of the desired product.

1. customreturned to 20° C
2. extractionextracted with ether
3. customThe ether phase was evaporated to dryness under reduced pressure
4. distillationthe 27.4 g of residue were distilled under reduced pressure (0.05 mbar) at 79/83° C.
5. customto obtain

ORD 기록

ord-80483b027e8842b2b353a06affbbfef9

출처 데이터셋

uspto-grants-1998_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05707982