2-Propenoic acid, 3-(2-chloro-4-fluorophenyl)- → 3-(2-Chloro-4-fluorophenyl)propanoic acid

HRID 726144

반응식

HRID 726144 반응식
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[H][H]>C(O)C.O.[Pt]=O>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

참가 물질

5

반응물 2

HCID 27250652-Propenoic acid, 3-(2-chloro-4-fluorophenyl)-HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 117695833-(2-Chloro-4-fluorophenyl)propanoic acid수율 101.4%

시약·촉매·용매 2

HCID 86587499Platinum oxide monohydrate촉매HCID 702Ethanol용매

실험 절차

A mixture of 2-chloro-4-fluorocinnamic acid (22.9 g, 0.11 mol) and platinum oxide hydrate (0.5 g, EM Scientific) in 95% ethanol (140 ml) was placed on a Parr hydrogenation apparatus. After the appropriate amount of hydrogen was taken up, the catalyst was filtered and the mixture was concentrated in vacuo to give 22.6 g (98%) of 3-(2-chloro-4-fluorophenyl)propanoic acid as a purple solid. This material was used without further purification.

후처리

  1. filtrationthe catalyst was filtered
  2. concentrationthe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-42500ebc25824cfa82c7d3a5689ba03c
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05708033

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