Histamine → HCID 178526675, 화합물
반응식
[CH:1]1[N:5]=[CH:4][NH:3][C:2]=1[CH2:6][CH2:7][NH2:8].Cl[C:10]1[C:15]([N+:16]([O-:18])=[O:17])=[CH:14][CH:13]=[CH:12][N:11]=1>CC(O)C>[NH:5]1[CH:1]=[C:2]([CH2:6][CH2:7][NH:8][C:10]2[C:15]([N+:16]([O-:18])=[O:17])=[CH:14][CH:13]=[CH:12][N:11]=2)[N:3]=[CH:4]1참가 물질
4
실험 절차
1.14 g (10.2 mmol) of histamine base and 1.62 g (10.2 mmol) of 2-chloro-3-nitropyridine are brought to reflux in 5 ml of 2-propanol for 3 h. Evaporation of the solvent under reduced pressure and purification of the solid residue by chromatography on a column of silica gel, eluted with chloroform containing increasing amounts of methanol (5, 10 and 20%), provide the title compound. M.p.: 178°-180° C. (yield 65%; ethanol:water).
후처리
- customEvaporation of the solvent
- customunder reduced pressure and purification of the solid residue by chromatography on a column of silica gel
- washeluted with chloroform containing
- temperatureincreasing amounts of methanol (5, 10 and 20%)
출처 및 근거
- ORD 기록
- ord-f9521c8bab444beabdf8881f699debc0
- 출처 데이터셋
- uspto-grants-1998_01
- 특허 번호
- US05708171
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