4-fluoro-N-(4-nitrophenyl)benzamide → N-(4-Aminophenyl)-4-fluorobenzamide

HRID 726337노트

반응식

HRID 726337 반응식
[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1.[H][H]>O1CCCC1.[Pt]>[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 39484284-fluoro-N-(4-nitrophenyl)benzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 10988055N-(4-Aminophenyl)-4-fluorobenzamide수율 98.7%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 56.6 gm (0.217 mole) 4-(4-fluorobenz-oyl)aminonitrobenzene in 875 mL tetrahydrofuran were added 5.7 gm 5% platinum on carbon. The reaction mixture was hydrogenated at room temperature for 18 hours at initial hydrogen pressure of 60 p.s.i. The reaction mixture was then filtered and the filtrate concentrated under reduced pressure to give 49.3 gm (98.5%) of the desired compound.

후처리

  1. filtrationThe reaction mixture was then filtered
  2. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ccf2297eda5a41cc90426f03eaece458
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05708187

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