Acetic Acid → Benzenemethanol, 4-nitro-, 1-acetate

HRID 726480

반응식

HRID 726480 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][OH:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:12](OC(=O)C)(=[O:14])[CH3:13].C(O)(=O)C>O>[C:12]([O:9][CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:11][CH:10]=1)(=[O:14])[CH3:13]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 692754-Nitrobenzyl alcohol

생성물 1

HCID 12094Benzenemethanol, 4-nitro-, 1-acetate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

7.6 g (0.05 mol) of 4-nitrobenzyl alcohol, 4.7 ml (0.05 mol) of acetic anhydride and 5.8 ml (0.1 mol) of acetic acid were introduced into a round-bottomed flask and the mixture was heated at reflux for eight hours. The reaction medium was poured into water, extracted with ethyl ether, the organic phase decanted off, dried over magnesium sulfate and evaporated. The residue was triturated in hexane, filtered and dried. 6.1 g (62%) of 4-nitrobenzyl acetate of melting point 77°-78° C. were recovered.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for eight hours
  3. extractionextracted with ethyl ether
  4. customthe organic phase decanted off
  5. dry with materialdried over magnesium sulfate
  6. customevaporated
  7. customThe residue was triturated in hexane
  8. filtrationfiltered
  9. customdried
  10. custom6.1 g (62%) of 4-nitrobenzyl acetate of melting point 77°-78° C. were recovered

출처 및 근거

ORD 기록
ord-688eb585bdcb494e85d1a56d24f7b9a6
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05709867

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