Hydrochloric Acid → HCID 178521548, 화합물

HRID 726511

반응식

HRID 726511 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl.[C:8]1([CH:14]2[CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>O1CCCC1>[C:8]1([C@H:14]2[CH2:15][CH2:16][C@H:17]([OH:20])[CH2:18][CH2:19]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 786054-PhenylcyclohexanoneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 178521548HCID 178521548, 화합물수율 71.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

First, 2 g of lithium aluminium hydride and 20 ml of tetrahydrofuran were placed in a 300 ml flask. Then, a solution in which 25 g of 4-phenylcyclohexanone was dissolved in 200 ml of tetrahydrofuran was added dropwise to the mixture at room temperature. The mixture was stirred under reflux for 1 hour. Diluted hydrochloric acid was added to the reaction mixture, and an organic layer was extracted with ether. The ether layer was washed with water and dried over anhydrous sodium sulfate. Thereafter, the solvent was distilled away. The residue was recrystallized from acetone to obtain 18 g of trans-4-phenylcyclohexanol (Y: 71.5%). The compound thus obtained had a purity of 98.4% by GC and an m.p. of 117° C. to 119° C.

후처리

  1. additionwas added dropwise to the mixture at room temperature
  2. temperatureunder reflux for 1 hour
  3. extractionan organic layer was extracted with ether
  4. washThe ether layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationThereafter, the solvent was distilled away
  7. customThe residue was recrystallized from acetone

출처 및 근거

ORD 기록
ord-eacfe205f6bc4d86bbadbf8687206cc1
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05709911

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