Carbon Tetrachloride → 2-Bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone

HRID 726548

반응식

HRID 726548 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.C(Cl)(Cl)Cl.C(Cl)(Cl)(Cl)Cl.[Br:30]Br>C(Cl)Cl>[Br:30][CH:9]([C:10]1[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:17])=[O:18])=[CH:12][CH:11]=1)[C:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:20]

참가 물질

6

반응물 4

HCID 5943Carbon TetrachlorideHCID 6212ChloroformHCID 24408BromineHCID 112433011-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)ethanone

생성물 1

HCID 112340792-Bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 1-(4-Fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone (1.00 g) in CH2Cl2 containing CHCl3 (1.0 mL) and CCl4 (1.0 mL) was added bromine (0.614 g). After shining light for 1 h, the reaction was quenched with Na2S2O4, extracted with CH2Cl2, dried over Na2SO4 and evaporated to yield the title compound which was used as such for the next step (1.10 g).

후처리

  1. customfor 1 h
  2. customthe reaction was quenched with Na2S2O4
  3. extractionextracted with CH2Cl2
  4. dry with materialdried over Na2SO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-1321687d3e724f1995026aef7b2f0174
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05710140

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