Hydrochloric Acid → 2-Oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid

HRID 726679노트

반응식

HRID 726679 반응식
C([O:3][C:4]([C:6]1[C:7](=[O:22])[NH:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:5])C.C(O)C.[OH-].[K+].Cl>O>[C:16]1([C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7](=[O:22])[C:6]=2[C:4]([OH:5])=[O:3])[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 151627361,2-Dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester

생성물 1

HCID 151627412-Oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid수율 93.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1,2-dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester (5 g, 17 mmol), ethanol (20 ml), water (40 ml) and potassium hydroxide (5 g, 89 mmol) was refluxed with heat for 1.5 hours. To the reaction mixture was added 60 ml of 2N-HCl to acidify the mixture to obtain a precipitated crystal by filtration. The crystal obtained was recrystallized from ethanol to give 4.2 g (yield: 92.9%) of the title compound.

후처리

  1. temperaturewas refluxed
  2. temperaturewith heat for 1.5 hours
  3. customto obtain a precipitated crystal
  4. filtrationby filtration
  5. customThe crystal obtained
  6. customwas recrystallized from ethanol

출처 및 근거

ORD 기록
ord-4006e22df06341da8c02a8bdfb625527
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05710162

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