Ethanol → Ethyl 3-Fluoro-4-nitrobenzoate

HRID 72765

반응식

HRID 72765 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([O:7][CH2:19][CH3:20])=[O:6]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 2306533-Fluoro-4-nitrobenzoic acid

생성물 1

HCID 45036938Ethyl 3-Fluoro-4-nitrobenzoate

실험 절차

To the liquid mixture of 3-fluoro-4-nitrobenzoic acid 9.71 g and ethanol 35 mL, cone. sulfuric acid 1.6 mL was added, followed by 16 hours' heating under reflux. After distilling the solvent off, water and tert-butyl methyl ether were added to the residue. The organic layer was extracted, washed with water and dried over magnesium sulfate. Distilling the solvent off, 7.40 g of the title compound was obtained.

후처리

  1. temperature' heating
  2. temperatureunder reflux
  3. distillationAfter distilling the solvent off, water and tert-butyl methyl ether
  4. additionwere added to the residue
  5. extractionThe organic layer was extracted
  6. washwashed with water
  7. dry with materialdried over magnesium sulfate
  8. distillationDistilling the solvent off, 7.40 g of the title compound
  9. customwas obtained

출처 및 근거

ORD 기록
ord-2186fce3620a40909637c4fd0559f38d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829000B2

연결된 노트

불러오는 중…