Ethanol → Ethyl 3-Fluoro-4-nitrobenzoate

반응식

[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([O:7][CH2:19][CH3:20])=[O:6]

참가 물질

반응물 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 2306533-Fluoro-4-nitrobenzoic acid

생성물 1

HCID 45036938Ethyl 3-Fluoro-4-nitrobenzoate

실험 절차

To the liquid mixture of 3-fluoro-4-nitrobenzoic acid 9.71 g and ethanol 35 mL, cone. sulfuric acid 1.6 mL was added, followed by 16 hours' heating under reflux. After distilling the solvent off, water and tert-butyl methyl ether were added to the residue. The organic layer was extracted, washed with water and dried over magnesium sulfate. Distilling the solvent off, 7.40 g of the title compound was obtained.

후처리

temperature' heating
temperatureunder reflux
distillationAfter distilling the solvent off, water and tert-butyl methyl ether
additionwere added to the residue
extractionThe organic layer was extracted
washwashed with water
dry with materialdried over magnesium sulfate
distillationDistilling the solvent off, 7.40 g of the title compound
customwas obtained

출처 및 근거

ORD 기록: ord-2186fce3620a40909637c4fd0559f38d
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08829000B2

반응 노트

불러오는 중…