Piperidine → Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate

HRID 72773

반응식

HRID 72773 반응식
[CH:1]([C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1)=O.[C:14]([O:20][CH2:21][CH3:22])(=[O:19])[CH2:15]C([O-])=O.N1CCCCC1>N1C=CC=CC=1>[CH2:21]([O:20][C:14](/[CH:15]=[CH:1]/[C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1)=[O:19])[CH3:22]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 1113514ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylateHCID 3595298Propanedioic acid, monoethyl ester

생성물 1

HCID 59198650Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate수율 47.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.

후처리

  1. filtrationthe precipitate was recovered by filtration
  2. washThe precipitate was washed with water
  3. customdried
  4. temperatureunder heating

출처 및 근거

ORD 기록
ord-fb2dddac9b4b492ab2f73cd7baa61606
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829000B2

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