Acetic Anhydride → Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]-

HRID 727740

반응식

HRID 727740 반응식
[OH:1][CH2:2][CH2:3][N:4]([C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][CH:8]=1)[CH2:5][CH3:6].[C:15](OC(=O)C)(=[O:17])[CH3:16].C(N(CC)CC)C>ClCCl>[C:15]([O:1][CH2:2][CH2:3][N:4]([C:7]1[CH:8]=[CH:9][C:10]([CH:11]=[O:12])=[CH:13][CH:14]=1)[CH2:5][CH3:6])(=[O:17])[CH3:16]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 6398574-(Ethyl(2-hydroxyethyl)amino)benzaldehyde

생성물 1

HCID 11458991Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]-

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 193.2 g (1 mole) of 4-(N-2-hydroxyethyl-N-ethylamino)benzaldehyde in dichloromethane are added 153.1 g (1.5 moles) of acetic anhydride, 151.8 g (1.5 moles) of triethylamine, and 8.5 g (7 mole %) of 4-N,N-dimethylaminopyridine. The reaction mixture is stirred at room temperature for 16 hours. The product solution then is washed with cold 2N HCl followed by saturated sodium bicarbonate, and the organic layer is filtered through cotton, and evaporated to dryness.

후처리

  1. washThe product solution then is washed with cold 2N HCl
  2. filtrationthe organic layer is filtered through cotton
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-7b16f812848842e7b74bc72ac5d97a46
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05044725

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