4-[1-(1-Imidazolyl)-butyl]-benzoic acid methyl ester → 4-[1-(1-Imidazolyl)-butyl]-benzoic acid

HRID 727842노트

반응식

HRID 727842 반응식
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)[CH2:11][CH2:12][CH3:13])=[CH:6][CH:5]=1>Cl>[N:14]1([CH:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:19])=[O:2])=[CH:5][CH:6]=2)[CH2:11][CH2:12][CH3:13])[CH:18]=[CH:17][N:16]=[CH:15]1

참가 물질

3

반응물 1

HCID 145143744-[1-(1-Imidazolyl)-butyl]-benzoic acid methyl ester

생성물 1

HCID 145143684-[1-(1-Imidazolyl)-butyl]-benzoic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

23 g of the ester of example 1 is refluxed in 200 ml of concentrated hydrochloric acid for 20 hours. After concentration by evaporation in a vacuum, the residue is dissolved in water and brought to pH 8 with 50% sodium hydroxide solution. Then it is adjusted to pH 5-6 with 1M hydrochloric acid and evaporated to dryness. The crystalline residue is boiled several times with ethyl acetate and filtered. After concentration by evaporation, 20 g of 4-[1-(1-imidazolyl)-butyl]-benzoic acid with a melting point of 171°-172° C. is obtained.

후처리

  1. concentrationAfter concentration
  2. customby evaporation in a vacuum
  3. dissolutionthe residue is dissolved in water
  4. customevaporated to dryness
  5. filtrationfiltered
  6. concentrationAfter concentration
  7. customby evaporation, 20 g of 4-[1-(1-imidazolyl)-butyl]-benzoic acid with a melting point of 171°-172° C.
  8. customis obtained

출처 및 근거

ORD 기록
ord-500fc82252e74c27a197681b055adeb0
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05045558

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