Sodium Hydroxide → 3-[(2-{[(1H-Benzimidazol-2-yl)sulfanyl]methyl}-3-methylpyridin-4-yl)oxy]propan-1-ol

HRID 727904노트

반응식

HRID 727904 반응식
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[CH2:12][C:13]1[C:18]([CH3:19])=[C:17]([O:20][CH2:21][CH2:22][CH2:23][OH:24])[CH:16]=[CH:15][N:14]=1.[OH-].[Na+]>C(O)C>[OH:24][CH2:23][CH2:22][CH2:21][O:20][C:17]1[CH:16]=[CH:15][N:14]=[C:13]([CH2:12][S:1][C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[C:18]=1[CH3:19]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 196005442-Chloromethyl-4-(3-hydroxypropoxy)-3-methylpyridineHCID 178527775HCID 178527775, 화합물

생성물 1

HCID 151662603-[(2-{[(1H-Benzimidazol-2-yl)sulfanyl]methyl}-3-methylpyridin-4-yl)oxy]propan-1-ol수율 56%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
50 °C

실험 절차

80 ml of ethanol was added to a mixture comprising 1.39 g (9.27 mmol) of 2-mercaptobenzimidazole, 2.0 g (9.27 mmol) of 2-chloromethyl-4-(3-hydroxypropoxy)-3-methylpyridine and 0.44 g (11.1 mmol) of sodium hydroxide. The obtained mixture was stirred at 50° C. for one hour. After the completion of the reaction, the reaction mixture was concentrated. The obtained residue was purified by silica gel column chromatography to obtain 1.7 g of the title compound (56%).

후처리

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated
  3. customThe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-0f5e17c2838f498aa71de24f3558e07e
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05045552

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