Sodium Hydroxide → 2-[4-(4-Methoxybutoxy)pyridine-2-yl]methylthio-1H-benzimidazole

HRID 727911노트

반응식

HRID 727911 반응식
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[CH2:12][C:13]1[CH:18]=[C:17]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25])[CH:16]=[CH:15][N:14]=1.[OH-].[Na+]>C(O)C>[CH3:25][O:24][CH2:23][CH2:22][CH2:21][CH2:20][O:19][C:17]1[CH:16]=[CH:15][N:14]=[C:13]([CH2:12][S:1][C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[CH:18]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 151662232-Chloromethyl-4-(4-methoxybutoxy)pyridineHCID 178527775HCID 178527775, 화합물

생성물 1

HCID 151663272-[4-(4-Methoxybutoxy)pyridine-2-yl]methylthio-1H-benzimidazole수율 70.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture comprising 2.55 g (0.017 mol) of 2-mercaptobenzimidazole, 5.09 g (0.022 mol) of 2-chloromethyl-4-(4-methoxybutoxy)pyridine, 0.84 g (0.020 mol) of 95% sodium hydroxide and 60 ml of ethanol was stirred at 40° C. for 1.5 hours. After the completion of the reaction, the reaction mixture was distilled to remove the solvent. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane) to obtain 4.13 g of the title compound.

후처리

  1. customAfter the completion of the reaction
  2. distillationthe reaction mixture was distilled
  3. customto remove the solvent
  4. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane)

출처 및 근거

ORD 기록
ord-727e4dcd8a5642c897b6465dfdf72cd8
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05045552

반응 노트

불러오는 중…