Chloroacetone → 2-Propanone, 1-((1-methyl-1H-tetrazol-5-yl)thio)-
반응식
O.[Na].[SH:3][C:4]1[N:8]([CH3:9])[N:7]=[N:6][N:5]=1.Cl[CH2:11][C:12](=[O:14])[CH3:13]>C(O)C>[CH3:9][N:8]1[C:4]([S:3][CH2:11][C:12]([CH3:13])=[O:14])=[N:5][N:6]=[N:7]1참가 물질
4
실험 절차
To a solution of 3.12 g (0.02 mol) of 5-mercapto-1-methyltetrazole sodium salt hydrate in 60 ml of absolute ethanol was added dropwise, 2.06 g (0.2 mol) of chloroacetone. After stirring for 20 hours at room temperature, the ethanol was evaporated in vacuo. The residue was dissolved in methylene chloride and was washed with water and then brine prior to drying over Na2SO4. Evaporation of the methylene chloride solution gave 1-methyl-5-acetonylthiotetrazole that was purified by flash chromatography on silica gel to yield 0.94 g of the 5-acetonylthio-1-methyltetrazole product.
후처리
- customthe ethanol was evaporated in vacuo
- dissolutionThe residue was dissolved in methylene chloride
- washwas washed with water
- dry with materialbrine prior to drying over Na2SO4
- customEvaporation of the methylene chloride solution
출처 및 근거
- ORD 기록
- ord-69deeb1296234ed9a1deaa3df3afcd02
- 출처 데이터셋
- uspto-grants-1991_09
- 특허 번호
- US05047416
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