Hydrochloric Acid → 2-(3,4-Bis(benzyloxy)phenyl)acetic acid

HRID 728073노트

반응식

HRID 728073 반응식
[OH-].[K+].[CH2:3]([O:10][C:11]1[CH:12]=[C:13]([CH2:25][C:26]([O:28]CC2C=CC=CC=2)=[O:27])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO>[CH2:3]([O:10][C:11]1[CH:12]=[C:13]([CH2:25][C:26]([OH:28])=[O:27])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 419522HCID 419522, 화합물

생성물 1

HCID 5618122-(3,4-Bis(benzyloxy)phenyl)acetic acid수율 78.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Potassium hydroxide (6.2 g) was added to a solution of benzyl 3,4-dibenzyloxyphenylacetate (16.0 g) in methanol (200 ml), followed by stirring at room temperature for 6 hours. The reaction mixture was adjusted to pH 4.0 with 5N hydrochloric acid solution. The solvent was distilled off and to the residue was added water. The precipitated crystal was collected by filtration, washed with water and dried to obtain as colorless crystal 3,4-dibenzyloxyphenylacetic acid (10.0 g).

후처리

  1. distillationThe solvent was distilled off and to the residue
  2. additionwas added water
  3. filtrationThe precipitated crystal was collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-a73f8cf75ef24949afbfa02650c3f78c
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05047430

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