Iodine → 1,9-Dimethylphenothiazin-5-ium iodide

HRID 72815

반응식

HRID 72815 반응식
[CH3:1][C:2]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][C:12]=3[CH3:16])[S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[I:17]I>C(Cl)(Cl)Cl>[I-:17].[CH3:16][C:12]1[C:13]2[C:8](=[S+:7][C:6]3[C:15]([N:14]=2)=[C:2]([CH3:1])[CH:3]=[CH:4][CH:5]=3)[CH:9]=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 807IodineHCID 674644911,9-dimethyl-10H-phenothiazine

생성물 1

HCID 890773051,9-Dimethylphenothiazin-5-ium iodide

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

1,9-Dimethylphenothiazine (4.2026 g, 18.49 mmol) was dissolved in 130 mL of chloroform and crushed iodine (14.1 g, 55.55 mmol, 3 eq.) dissolved in 520 mL of chloroform was added over 2 hurs. Once newly formed precipitate was filtered off or the solvent removed under vacuum, the resulting iodide salt was stirred with ether or hexane (sometimes overnight) to remove excess iodine then refiltered. After pumping down under vacuum, a brown precipitate was obtained as product (12.6 g).

후처리

  1. additionwas added over 2 hurs
  2. filtrationOnce newly formed precipitate was filtered off
  3. customthe solvent removed under vacuum
  4. customto remove excess iodine
  5. customa brown precipitate was obtained as product (12.6 g)

출처 및 근거

ORD 기록
ord-cedc4d50e13a4c5098b83e0fbcb6f8ee
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828986B2

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