Water → 1,2-Diphenylethyl-N-methylamine

HRID 728317

반응식

HRID 728317 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([NH:12][CH:13]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(OCC)=O.O.[OH-].[Na+]>O1CCCC1>[CH3:7][NH:12][CH:13]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 234956Ethyl (1,2-diphenylethyl)carbamateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 1109861,2-Diphenylethyl-N-methylamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a stirred suspension of lithium aluminum hydride (12.4 g, 0.32 mol) in 300 ml of tetrahydrofuran at 0° C. under nitrogen was added dropwise a solution of N-carboethoxy-1,2-diphenylethylamine (35.0 g, 0.13 mol) in 200 ml of tetrahydrofuran. The mixture was heated to reflux for 8 hours. The mixture was cooled in an ice-water bath and water (13 ml), 15% NaOH (13 ml) and water (39 ml) were carefully added to the mixture. The mixture was warmed to ambient temperature and the precipitated salts were removed by filtration through celite. Removal of solvent gave N-methyl-1,2-diphenylethylamine, 26.8 g as a colorless oil.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 8 hours
  3. temperatureThe mixture was cooled in an ice-water bath
  4. customthe precipitated salts were removed by filtration through celite
  5. customRemoval of solvent

출처 및 근거

ORD 기록
ord-3138c27f06f949bdb1d39ca69aa14bb2
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05047541

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