Hydrochloric Acid → HCID 19823951, 화합물

HRID 728408노트

반응식

HRID 728408 반응식
[N+:1]([C:4]1[CH:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].C(O)(=O)CC.Cl.[N:29]([O-])=O.[Na+].[CH3:33][N:34]([CH2:41][CH2:42][C:43]([OH:45])=[O:44])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.C([O-])(=O)C.[Na+]>C(O)(=O)C.O>[N+:1]([C:4]1[CH:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]=[CH:7][C:5]=1[N:6]=[N:29][C:38]1[CH:39]=[CH:40][C:35]([N:34]([CH3:33])[CH2:41][CH2:42][C:43]([OH:45])=[O:44])=[CH:36][CH:37]=1)([O-:3])=[O:2]

참가 물질

9

반응물 6

HCID 313Hydrochloric Acid2회HCID 1032Propionic AcidHCID 517045Sodium AcetateHCID 125224893-(Methylphenylamino)-propionic acidHCID 141221844-Dodecyl-2-nitroanilineHCID 23668193Sodium Nitrite

생성물 1

HCID 19823951HCID 19823951, 화합물수율 4%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

2-Nitro-4-dodecylaniline (3.06 g) was dissolved in acetic acid (15 ml) and propionic acid (15 ml) and warmed whilst dilute hydrochloric acid (5 ml) was added. The mixture was cooled to 0° C. and sodium nitrite (0.7 g) was added at 0° C. The diazotised amine was then added to N-methyl-N-(2-hydroxycarbonylethyl)aniline (1.79 g) in water (100 ml) with dilute hydrochloric acid (3 ml). Sodium acetate was added until colour developed and the mixture was stirred for 0.5 hours. The crude product was recrystallised from CH2Cl2 to give a red solid (0.2 g).

후처리

  1. additionwas added
  2. customThe crude product was recrystallised from CH2Cl2

출처 및 근거

ORD 기록
ord-4deca5fba76847d99c067e762b2e0a36
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05047516

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