2-Acetoxymethyl-4-cyclopropylmethoxy pyridine → 4-Cyclopropylmethoxy-2-hydroxymethylpyridine

HRID 728638노트

반응식

HRID 728638 반응식
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[CH:9]=[CH:8][N:7]=1)(=O)C>[OH-].[Na+]>[CH:14]1([CH2:13][O:12][C:10]2[CH:9]=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[CH:11]=2)[CH2:15][CH2:16]1

참가 물질

3

반응물 1

HCID 156624932-Acetoxymethyl-4-cyclopropylmethoxy pyridine

생성물 1

HCID 108450754-Cyclopropylmethoxy-2-hydroxymethylpyridine

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

To the crude 2-acetoxymethyl-4-cyclopropylmethoxy pyridine, NaOH (100 ml 2 M) was added and the mixture was refluxed for 2 hours. The mixture was extracted with methylene chloride, and the phases were separated. The organic layer was dried with Na2SO4, filtered and the solvent was evaporated off, yielding 2.7 g of crude title compound. NMR data is given below. The crude product was used without any further purification.

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. extractionThe mixture was extracted with methylene chloride
  3. customthe phases were separated
  4. dry with materialThe organic layer was dried with Na2SO4
  5. filtrationfiltered
  6. customthe solvent was evaporated off

출처 및 근거

ORD 기록
ord-824fdeaf16344337999e8564cf3cd681
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05049674

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