Water → 1-Benzylcyclobutane-1-carboxylic acid

HRID 728696노트

반응식

HRID 728696 반응식
[C:1]1([CH2:7][C:8]2([C:12]([O:14]CC)=[O:13])[CH2:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].O>C(O)C>[C:1]1([CH2:7][C:8]2([C:12]([OH:14])=[O:13])[CH2:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 962Water2회HCID 14798Sodium HydroxideHCID 15632049Ethyl 1-benzylcyclobutanecarboxylate

생성물 1

HCID 156705181-Benzylcyclobutane-1-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of ethyl 1-phenylmethylcyclobutanecarboxylate (4.16 g, 19.1 mmol), sodium hydroxide (1.2 g, 30 mmol) in ethanol (95%, 20 ml and water (5 ml) was stirred at room temperature for 60 hours. The reaction mixture was poured into cold water and extracted with diethyl ether. The aqueous Phase was separated, acidified with HCl (2N, 35 ml) and extracted with diethyl ether. The latter extract was washed with water, dried, filtered and evaporated to afford the desired product as a pale yellow oil: NMR (CDCl3) δ=1.7~2.6 (6H, m), 3.10 (2H, s), 7.22 (5H, s).

후처리

  1. extractionextracted with diethyl ether
  2. customThe aqueous Phase was separated
  3. extractionextracted with diethyl ether
  4. extractionThe latter extract
  5. washwas washed with water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-6372054f83d24c2b88224dd64c05a094
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05049696

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