Formic Acid → S-[2-(diethylamino)ethyl]-S-[4-(1H-imidazol-1-yl)-1,2,5-thiadiazol-3-yl]-N-methylsulfoximine

HRID 728795노트

반응식

HRID 728795 반응식
[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][CH2:5][S:6]([C:9]1[C:13]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)=[N:12][S:11][N:10]=1)(=[NH:8])=[O:7])[CH3:2].C=O.[CH:23](O)=O.[OH-].[Na+]>O>[CH2:19]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][S:6]([C:9]1[C:13]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)=[N:12][S:11][N:10]=1)(=[N:8][CH3:23])=[O:7])[CH3:20]

참가 물질

6

반응물 4

HCID 284Formic AcidHCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 57202344S-[2-(diethylamino)ethyl]-S-[4-(1H-imidazol-1-yl)-1,2,5-thiadiazol-3-yl]sulfoximine

생성물 1

HCID 57269155S-[2-(diethylamino)ethyl]-S-[4-(1H-imidazol-1-yl)-1,2,5-thiadiazol-3-yl]-N-methylsulfoximine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of S-[2-(diethylamino)ethyl]-S-[4-(1H-imidazol-1-yl)-1,2,5-thiadiazol-3-yl]sulfoximine (30 mmol), 17 ml of 37% formaldehyde and 22.6 ml of 98% formic acid is heated at reflux temperature for 48 hr. Water is added to the reaction mixture which is then made slightly basic by addition of 50% sodium hydroxide solution. The mixture is extracted with chloroform and the extract is dried and concentrated to obtain the title compound.

후처리

  1. temperatureis heated
  2. temperatureat reflux temperature for 48 hr
  3. extractionThe mixture is extracted with chloroform
  4. customthe extract is dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e8102cd87ae845cd9221abffa9032293
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05051420

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