2-((1-Naphthalenyloxy)methyl)oxirane → 1-[2-Hydroxy-3-(1-naphthalenyloxy)propyl]-4-[4-[(methylsulfonyl)amino]benzoyl]piperazine

HRID 728830노트

반응식

HRID 728830 반응식
[O:1]1[CH:3]([CH2:4][O:5][C:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8][CH:7]=2)[CH2:2]1.[CH3:16][S:17]([NH:20][C:21]1[CH:34]=[CH:33][C:24]([C:25]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[O:26])=[CH:23][CH:22]=1)(=[O:19])=[O:18]>CO>[OH:1][CH:3]([CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1)[CH2:2][N:30]1[CH2:31][CH2:32][N:27]([C:25](=[O:26])[C:24]2[CH:33]=[CH:34][C:21]([NH:20][S:17]([CH3:16])(=[O:19])=[O:18])=[CH:22][CH:23]=2)[CH2:28][CH2:29]1

참가 물질

4

반응물 2

HCID 915212-((1-Naphthalenyloxy)methyl)oxiraneHCID 147398841-[4-[(Methylsulfonyl)amino]benzoyl]piperazine

생성물 1

HCID 147398851-[2-Hydroxy-3-(1-naphthalenyloxy)propyl]-4-[4-[(methylsulfonyl)amino]benzoyl]piperazine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Add 7.89 g (42.4 mmol) of 1,2-epoxy-3-(1-naphthalenyloxy)propane to a solution of 12.0 9 (42.4 mmol) of 1-[4-[(methylsulfonyl)amino]benzoyl]piperazine in methanol. Heat the resultant solution at reflux for about 46 h. Cool the solution to room temperature and evaporate the solvent. Triturate the residue with ether toobtain crystals of the title compound.

후처리

  1. temperatureat reflux for about 46 h
  2. customevaporate the solvent
  3. customTriturate the residue with ether toobtain crystals of the title compound

출처 및 근거

ORD 기록
ord-eecd2b2f781d4955ac837ac98093689d
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05051423

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