Triethyl phosphite → HCID 86745084, 화합물

반응식

[CH2:1]([O:3][C:4](=[O:14])[CH:5]([NH:11][CH:12]=[O:13])[CH:6](O)[C:7]([CH3:9])=[CH2:8])[CH3:2].S(Br)(Br)=O.[P:19]([O:26]CC)([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22]>>[CH2:1]([O:3][C:4](=[O:14])[CH:5]([NH:11][CH:12]=[O:13])/[CH:6]=[C:7](\[CH3:9])/[CH2:8][P:19]([O:23][CH2:24][CH3:25])([O:20][CH2:21][CH3:22])=[O:26])[CH3:2]

참가 물질

반응물 3

HCID 31215Triethyl phosphite

HCID 68176Thionyl bromide

HCID 14332470HCID 14332470, 화합물

생성물 1

HCID 86745084HCID 86745084, 화합물

실험 절차

By reaction of 2-formylamino-3-hydroxy-4-methyl-4-pentenoic acid ethyl ester with thionyl bromide and subsequent treatment with triethyl phosphite in a manner analogous to that described in Example 1, E-2-formylamino-4-methyl-5-diethylphosphono-3-pentenoic acid ethyl ester is obtained in the form of a pale yellow oil.

출처 및 근거

ORD 기록: ord-0e5b50896e0d4e499f8de79556ac206b
출처 데이터셋: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05051413

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