Propylene Oxide → (3-Aminopropyl)(n-butyl)phosphinic acid
반응식
C(OC([NH:11][CH2:12][CH2:13][CH2:14][P:15]([CH2:18][CH2:19][CH2:20][CH3:21])(=[O:17])[OH:16])=O)C1C=CC=CC=1.C1OC1C>Cl.CO>[NH2:11][CH2:12][CH2:13][CH2:14][P:15]([CH2:18][CH2:19][CH2:20][CH3:21])(=[O:16])[OH:17]참가 물질
5
실험 절차
A solution of 6.7 g of 3-(benzyloxycarbonylamino)propyl(n-butyl) phosphinicacid in 125 ml of 36% hydrochloric acid is heated at reflux for 1.5 hour. The mixture is evaporated to an oil and the oil is co-evaporated with water (2×50 ml) to give a white solid. This solid is then dissolved in 50 ml of dry methanol, 1-3 ml of propylene oxide is added and the solution is stirred at room temperature. The precipitated product is collected by filtration and dried to give 3-aminopropyl(n-butyl) phosphinic acid, m.p. 231°-234° (dec.), 31P-NMR : δ=+44.6 ppm (D2O).
후처리
- temperatureat reflux for 1.5 hour
- customThe mixture is evaporated to an oil
- customto give a white solid
- filtrationThe precipitated product is collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-5bb8a276d43748b4ba57e8bf950758bd
- 출처 데이터셋
- uspto-grants-1991_09
- 특허 번호
- US05051524
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