P-Anisidine → 4-[(4-Methoxyphenyl)amino]-2-methyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

HRID 729307

반응식

HRID 729307 반응식
Cl[C:2]1[C:3](=[O:16])[N:4]([CH3:15])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:17][O:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:25]=[CH:24][C:22]([NH:23][C:2]2[C:3](=[O:16])[N:4]([CH3:15])[S:5](=[O:14])(=[O:13])[C:6]=2[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:21][CH:20]=1

참가 물질

3

반응물 2

HCID 7732P-AnisidineHCID 686620174-Chloro-2-methyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

생성물 1

HCID 116958744-[(4-Methoxyphenyl)amino]-2-methyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

실험 절차

The title compound was prepared from 4-chloro-2-methyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 4-methoxyaniline in a similar manner as described for e.g. Examples 9 and 13. 1H NMR (400 MHz, CD3CN): δ 7.67 (bs, 1H), 7.27-7.22 (m, 1H), 7.18-7.10 (m, 4H), 6.78-6.73 (m, 2H), 6.57-6.52 (m, 2H), 3.65 (s, 3H), 3.20 (s, 3H); Mass Spectrum: M+H+ 345.

출처 및 근거

ORD 기록
ord-281e18fb8f1c43d7bd4083f72d89ed51
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582629B2

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