1-Methyl-4-piperidone → HCID 1476965, 화합물

HRID 729639노트

반응식

HRID 729639 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH:14]=[C:4]1[C:5](=[O:8])[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]1)[CH3:13]

참가 물질

4

반응물 2

HCID 740491-Methyl-4-piperidoneHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 1476965HCID 1476965, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 1-methylpiperidin-4-one (10 g, 88 mmol) in toluene (100 mL) was added 1,1-dimethoxy-N,N-dimethylmethanamine (52.7 g, 0.442 mol). The solution was heated to reflux overnight. The solvents were evaporated in vacuo, heptane (100 ml) was added and the solvents evaporated again to give the desired product. NMR indicated that the product was 70-80% pure and it was used in the next step without further purification.

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux overnight
  3. customThe solvents were evaporated in vacuo, heptane (100 ml)
  4. additionwas added
  5. customthe solvents evaporated again

출처 및 근거

ORD 기록
ord-1878070c0c26483a8a9bc4ce5011bea2
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582643B2

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