Pyrrolidine → 4-(Pyrrolidine-1-sulfonyl)benzoic acid

HRID 72974

반응식

HRID 72974 반응식
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1>ClCCl>[N:14]1([S:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)(=[O:4])=[O:3])[CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 31268PyrrolidineHCID 823854-(Chlorosulfonyl)benzoic acid

생성물 1

HCID 7636514-(Pyrrolidine-1-sulfonyl)benzoic acid수율 30.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 4-chlorosulfonylbenzoic acid (2 g, 9.07 mmol) in dichloromethane (10 mL) was added a solution of pyrrolidine (1.29 g, 1.51 mL, 18.1 mmol) in dichloromethane (10 mL) and the reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was filtered and the white solid obtained was washed with water (50 ml) and diethyl ether (10 ml) and dried under vacuum to give 4-pyrrolidin-1-ylsulfonylbenzoic acid (700 mg, 30%). ESI-MS m/z calc. 255.0. Found 256.3 (M+1)+; Retention time: 1.18 minutes (3 min run); 1H NMR (400 MHz, DMSO) δ 13.49 (s, 1H), 8.15 (d, J=8.5 Hz, 2H), 7.92 (d, J=8.5 Hz, 2H), 3.17 (t, J=6.7 Hz, 4H), 1.65 (t, J=6.7 Hz, 4H).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe white solid obtained
  3. washwas washed with water (50 ml) and diethyl ether (10 ml)
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-0485f254a93b4844907c5f29d2a44550
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828996B2

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