Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylacetamide → 2-tert-Butyl-4-(4-fluorophenyl)oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylacetamide | HCID 12957 | — |
| 반응물 | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-tert-Butyl-4-(4-fluorophenyl)oxazole | HCID 66869043 | 1,254.2% |
반응 단계
Reflux a solution of commercially available 2-bromo-4′-fluoroacetophenone (100.00 g, 460 mmol), 2,2-dimethyl-propionamide (93.06 g, 20 mmol) in 1,4-dioxane (600 mL) for 2 days. Filter precipitate, concentrate filtrate, and purify (silica gel chromatography, eluting with hexanes:EtOAc 60:1) to give the title compound (55 g, 55%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582652B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-52788692ddab4fcba992ec967028d476 |
| 출처 메모 | uspto-grants-2009_09 |