4,4'-Difluorobenzophenone → N-[Bis(4-fluorophenyl)methyl]formamide

HRID 730429노트

반응식

HRID 730429 반응식
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=O)=[CH:4][CH:3]=1.[CH:17]([O-:19])=O.[NH4+:20]>O>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([NH:20][CH:17]=[O:19])[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 95824,4'-DifluorobenzophenoneHCID 2723923Ammonium formate

생성물 1

HCID 25126459N-[Bis(4-fluorophenyl)methyl]formamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
170 °C

실험 절차

A mixture of 4,4′-difluorobenzophenone (15.0 g, 68.7 mmol) and ammonium formate (35.3 g, 559 mmol) was stirred at 170° C. for 10 hours. The reaction solution was poured into water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the objective product as a solid material.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-eb2c72aa499245f4bd326ccde6b7d88e
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582651B2

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