Diisopropylethylamine → HCID 57835161, 화합물

HRID 730710

반응식

HRID 730710 반응식
[Br:1][C:2]1[C:10]2[N:9]=[C:8](Cl)[NH:7][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.Cl.[Cl:17][C:18]1[C:19]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[N:20][CH:21]=[CH:22][CH:23]=1.C(N(CC)C(C)C)(C)C>>[Br:1][C:2]1[C:10]2[N:9]=[C:8]([N:27]3[CH2:28][CH2:29][N:24]([C:19]4[C:18]([Cl:17])=[CH:23][CH:22]=[CH:21][N:20]=4)[CH2:25][CH2:26]3)[NH:7][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 115945854-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazoleHCID 204550741-(3-Chloropyridin-2-yl)piperazine hydrochloride

생성물 1

HCID 57835161HCID 57835161, 화합물

실험 절차

The benzoimidazole from step (b) above (210 mg, 0.7 mmol), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (187 mg, 0.8 mmol, Example 3b) and N,N-diisopropylethylamine (0.28 mL, 1.6 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 461 (M+1).

출처 및 근거

ORD 기록
ord-a5b79370abf1451baa3c44191cb46ddb
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582761B2

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